Dynamical brain connectivity markers in presymptomatic Alzheimer’s disease

Jazmín Ximena Suárez Revelo, John Fredy Ochoa Gomez, Jon Edinson Duque Grajales, Carlos Andres Tobón Quintero


Alzheimer's disease is the most prevalent cause of dementia generally with an onset after the 65 years. However, there are some genetic mutations that induce the onset of the neurocognitive symptoms before that age. The study of mutation carriers provides a unique opportunity to identify early preclinical changes related to Alzheimer's disease. The Event Related Potentials are a powerful tool used for the study of the neural substrates of cognitive function and deterioration. The connectivity analysis emerges as an alternative to the average approach typical in Event Related Potentials. In the current work two groups, mutation carriers and non-carriers, perform a memory task during Electroencephalography recording. Brain graphs are built at different time points using the directed Direct Transfer Function. Our results show how the dynamical study of the connectivity might help to detect neuronal changes in preclinical stage of Alzheimer's disease.

Palabras clave

Familial Alzheimer disease; Electroencephalography; Effective connectivity; Dynamical brain graphs

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Universidad Antonio Nariño - Sede Circunvalar

Carrera 3 Este No 47 A - 15, Bloque 4, Piso 3

Bogotá, Colombia

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ISSN 2145-0935 ISSN online: 2346-1446